  {"id":1192,"date":"2019-02-27T14:45:36","date_gmt":"2019-02-27T20:45:36","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/cit\/?page_id=1192"},"modified":"2025-04-09T11:28:09","modified_gmt":"2025-04-09T17:28:09","slug":"quality-metabolomics-research","status":"publish","type":"page","link":"https:\/\/www.vanderbilt.edu\/cit\/quality-metabolomics-research\/","title":{"rendered":"Focus on Quality"},"content":{"rendered":"<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-0  el_before_av_hr  avia-builder-el-first  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>A Comprehensive Approach<\/h3>\n<p>The Center for Innovative Technology (CIT) has established and implemented a quality management system that includes<span style=\"color: #000000\"><strong> quality assurance<\/strong><\/span> and <span style=\"color: #000000\"><strong>quality control<\/strong><\/span> practices for targeted and untargeted molecular omics\u00a0studies to ensure reproducible measurements and data standardization among different instrumentation platforms. In addition, the Center has experience participating in <a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.analchem.7b01729\" target=\"_blank\" rel=\"noopener\">cross-laboratory validation studies<\/a>. Our subject-matter experts have\u00a0<span style=\"color: #000000\"><strong>over 50 years of combined experience<\/strong><\/span>\u00a0in mass spectrometry, data analysis, and informatics pipelines.<\/p>\n<p>Finally, we regularly review scientific literature and\u00a0<a href=\"https:\/\/epi.grants.cancer.gov\/Consortia\/mQACC\/\" target=\"_blank\" rel=\"noopener\">metabolomics Quality Assurance and Quality Control Consortium (mQACC)<\/a>\u00a0guidelines for metabolomics research and reporting as they become available. \u00a0The Consortium\u2019s recommendations are incorporated into our comprehensive\u00a0<span style=\"color: #000000\"><strong>Quality Management System<\/strong><\/span>\u00a0and reviewed regularly for updates or changes.<\/p>\n<\/div><\/section><br \/>\n<div  style='height:40px' class='hr hr-invisible   avia-builder-el-2  el_after_av_textblock  el_before_av_image '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<div  class='avia-image-container avia_animated_image avia_animate_when_almost_visible fade-in av-styling- av-hover-grow   avia-builder-el-3  el_after_av_hr  avia-builder-el-last  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='wp-image-1270 avia-img-lazy-loading-not-1270 avia_image' src=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05115443\/Quality-System-1000.png\" alt='Metabolomics Quality Assurance and Control' title='Metabolomics Quality Assurance and Control' height=\"314\" width=\"1000\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05115443\/Quality-System-1000.png 1000w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05115443\/Quality-System-1000-300x94.png 300w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05115443\/Quality-System-1000-768x241.png 768w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05115443\/Quality-System-1000-705x221.png 705w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05115443\/Quality-System-1000-450x141.png 450w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/div><\/div><\/div><\/p><\/div><div  style='height:75px' class='hr hr-invisible   avia-builder-el-4  el_after_av_one_full  el_before_av_one_half '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><\/p>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding first  avia-builder-el-5  el_after_av_hr  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center\">Quality Assurance (QA)<\/h3>\n<p>Quality assurance allows us to ensure that methods are designed in such way they result in high-quality outcomes.<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-icon-list-container   avia-builder-el-7  el_after_av_textblock  avia-builder-el-last '><ul class='avia-icon-list avia-icon-list-left av-iconlist-big avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue84b' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Quality Management Plan<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue83c' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Requirements Elicitation<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>i.e., communicate and elicit detailed requirements in order to determine the best analytical approach, limitations, opportunities, and value<\/p>\n<p>See our <a href=\"https:\/\/www.vanderbilt.edu\/cit\/metabolomics-sample-replicates\/\" target=\"_blank\" rel=\"noopener\">requirements for sample quantity and replicates<\/a>.<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue856' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Maintenance &amp; Calibration<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>for all laboratory instrumentation and equipment<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue850' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Standard Operating Procedures<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., sample storage, sample preparation and extraction, instrument setup, QC sample assessment, data analysis, data handling<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue80a' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Staff Training<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., training for instrumentation, data analysis, and lab safety<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue80b' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Communicating Sample Quality Requirements<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., raising awareness w\/ collaborators in regard to <a href=\"https:\/\/www.vanderbilt.edu\/cit\/metabolomics-sample-storage-and-handling\/\" target=\"_blank\" rel=\"noopener\">sampling, sample handling and storage conditions<\/a><\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue8da' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Data Handling &amp; Traceability<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., samples, sample results, analytical supplies<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/p><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-8  el_after_av_one_half  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center\">Quality Control (QC)<\/h3>\n<p>Quality control processes allow us to ensure that methods were applied correctly and analytical performance meets predefined standards.<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-icon-list-container   avia-builder-el-10  el_after_av_textblock  avia-builder-el-last '><ul class='avia-icon-list avia-icon-list-left av-iconlist-big avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue896' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Inter-Laboratory Comparisons (ILC)<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., for <a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.analchem.7b01729\" target=\"_blank\" rel=\"noopener\">collaborative method validation studies<\/a><\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue8de' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Instrument Performance Checks<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>to validate conformance with pre-defined performance parameters (e.g., recovery)<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue8ba' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Standards &amp; Certified Reference Materials<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., to validate annotations and provide traceability<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue894' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Randomization of Samples<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>to guard against technical bias<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue8cc' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Sample Replicates<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., biological, technical<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue8cd' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Preparation &amp; Inclusion of QC Samples<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><p>e.g., sample blanks, pooled samples<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='background-color:#52bef0; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue8a8' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Performance Monitoring &amp; Analysis over Time<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/p><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding first  avia-builder-el-11  el_after_av_one_half  el_before_av_one_half  column-top-margin\" style='border-radius:0px; '><div  class='avia-image-container avia_animated_image avia_animate_when_almost_visible fade-in av-styling- av-hover-grow   avia-builder-el-12  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='wp-image-1197 avia-img-lazy-loading-not-1197 avia_image' src=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123800\/IMG_4597_600.jpg\" alt='Metabolomics Quality Assurance' title='Metabolomics Quality Assurance' height=\"359\" width=\"600\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123800\/IMG_4597_600.jpg 600w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123800\/IMG_4597_600-300x180.jpg 300w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123800\/IMG_4597_600-450x269.jpg 450w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-13  el_after_av_one_half  el_before_av_hr  column-top-margin\" style='border-radius:0px; '><div  class='avia-image-container avia_animated_image avia_animate_when_almost_visible fade-in av-styling- av-hover-grow   avia-builder-el-14  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='wp-image-1196 avia-img-lazy-loading-not-1196 avia_image' src=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123749\/business-2089533_600.jpg\" alt='Metabolomics Quality Control' title='Metabolomics Quality Control' height=\"359\" width=\"600\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123749\/business-2089533_600.jpg 600w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123749\/business-2089533_600-300x180.jpg 300w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/02\/25123749\/business-2089533_600-450x269.jpg 450w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/div><\/div><\/div><\/div>\n<div  style='height:90px' class='hr hr-invisible   avia-builder-el-15  el_after_av_one_half  el_before_av_section  avia-builder-el-last '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1'  class='avia-section main_color avia-section-small avia-no-shadow  avia-bg-style-scroll  avia-builder-el-16  el_after_av_hr  el_before_av_hr   container_wrap sidebar_right' style='background-color: #e1e1e1;  '  ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-1192'><div class='entry-content-wrapper clearfix'>\n<div  style='height:20px' class='hr hr-invisible   avia-builder-el-17  el_before_av_textblock  avia-builder-el-first '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center\">Additional Client Resources:<\/h3>\n<\/div><\/section>\n<div  style='height:20px' class='hr hr-invisible   avia-builder-el-19  el_after_av_textblock  el_before_av_one_fourth '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"flex_column av_one_fourth  no_margin flex_column_div av-zero-column-padding first  avia-builder-el-20  el_after_av_hr  el_before_av_one_fourth  \" style='border-radius:0px; '><div  class='avia-button-wrap avia-button-right  avia-builder-el-21  avia-builder-el-no-sibling ' ><a href="https:\/\/www.vanderbilt.edu\/cit\/metabolomics-sample-replicates\/"  class='avia-button  avia-color-theme-color-subtle   avia-icon_select-no avia-size-medium avia-position-right '   ><span class='avia_iconbox_title' >Sample Replicates &amp; Volumes<\/span><\/a><\/div><\/div><div class=\"flex_column av_one_fourth  no_margin flex_column_div av-zero-column-padding   avia-builder-el-22  el_after_av_one_fourth  el_before_av_one_fourth  \" style='border-radius:0px; '><div  class='avia-button-wrap avia-button-center  avia-builder-el-23  avia-builder-el-no-sibling ' ><a href="https:\/\/www.vanderbilt.edu\/cit\/metabolic-quenching\/"  class='avia-button  avia-color-theme-color-subtle   avia-icon_select-no avia-size-medium avia-position-center '   ><span class='avia_iconbox_title' >Metabolic Quenching<\/span><\/a><\/div><\/div><div class=\"flex_column av_one_fourth  no_margin flex_column_div av-zero-column-padding   avia-builder-el-24  el_after_av_one_fourth  el_before_av_one_fourth  \" style='border-radius:0px; '><div  class='avia-button-wrap avia-button-center  avia-builder-el-25  avia-builder-el-no-sibling ' ><a href="https:\/\/www.vanderbilt.edu\/cit\/metabolomics-sample-storage-and-handling\/"  class='avia-button  avia-color-theme-color-subtle   avia-icon_select-no avia-size-medium avia-position-center '   ><span class='avia_iconbox_title' >Sample Handling &amp; Storage<\/span><\/a><\/div><\/div><div class=\"flex_column av_one_fourth  no_margin flex_column_div av-zero-column-padding   avia-builder-el-26  el_after_av_one_fourth  el_before_av_hr  \" style='border-radius:0px; '><div  class='avia-button-wrap avia-button-left  avia-builder-el-27  avia-builder-el-no-sibling ' ><a href="https:\/\/www.vanderbilt.edu\/cit\/metabolite-identification-confidence-levels\/"  class='avia-button  avia-color-theme-color-subtle   avia-icon_select-no avia-size-medium avia-position-left '   ><span class='avia_iconbox_title' >Metabolite Identification Levels<\/span><\/a><\/div><\/div><div  style='height:20px' class='hr hr-invisible   avia-builder-el-28  el_after_av_one_fourth  avia-builder-el-last '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_1'  class='main_color av_default_container_wrap container_wrap sidebar_right' style=' '  ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-1192'><div class='entry-content-wrapper clearfix'>\n<div  style='height:80px' class='hr hr-invisible   avia-builder-el-29  el_after_av_section  el_before_av_one_half  avia-builder-el-first '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class='flex_column_table av-equal-height-column-flextable -flextable' ><div class=\"flex_column av_one_half  flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding first  avia-builder-el-30  el_after_av_hr  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center\">Biological Factors to Consider<\/h3>\n<p>Aside from potential analytical sources of variation, which are being addressed by the detailed quality management system described above, a variety of biological factors for potential variation exist. This is especially true for human and animal-derived samples. These factors should be considered during the experimental design stage.<\/p>\n<\/div><\/section><br \/>\n<div  style='height:15px' class='hr hr-invisible   avia-builder-el-32  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>The CIT works closely together with the <a href=\"https:\/\/www.vumc.org\/cqs\/\" target=\"_blank\" rel=\"noopener\">Center for Quantitative Sciences<\/a> at Vanderbilt. If needed, we can determine the best statistical approach for your experimental design and advanced analysis in order to take various biological factors into consideration.<\/p>\n<\/div><\/section><br \/>\n<div  style='height:15px' class='hr hr-invisible   avia-builder-el-34  el_after_av_textblock  el_before_av_button '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<div  class='avia-button-wrap avia-button-center  avia-builder-el-35  el_after_av_hr  avia-builder-el-last ' ><a href="https:\/\/www.vanderbilt.edu\/cit\/contact-us\/"  class='avia-button av-icon-on-hover avia-color-theme-color   avia-icon_select-yes-left-icon avia-size-x-large avia-position-center '   ><span class='avia_button_icon avia_button_icon_left ' aria-hidden='true' data-av_icon='\ue8b7' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Contact Us<\/span><\/a><\/div><\/p><\/div>\n<div class='av-flex-placeholder'><\/div><div class=\"flex_column av_one_half  flex_column_table_cell av-equal-height-column av-align-middle av-zero-column-padding   avia-builder-el-36  el_after_av_one_half  avia-builder-el-last  \" style='border-radius:0px; '><div  class='avia-image-container avia_animated_image avia_animate_when_almost_visible fade-in av-styling- av-hover-grow   avia-builder-el-37  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='wp-image-1272 avia-img-lazy-loading-not-1272 avia_image' src=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05120021\/Biological-Variability_6001.png\" alt='Biological-Variability-Metabolomics' title='Biological-Variability-Metabolomics' height=\"420\" width=\"600\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05120021\/Biological-Variability_6001.png 600w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05120021\/Biological-Variability_6001-300x210.png 300w, https:\/\/cdn.vanderbilt.edu\/vu-wp0\/wp-content\/uploads\/sites\/166\/2019\/03\/05120021\/Biological-Variability_6001-450x315.png 450w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. 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