{"id":41,"date":"2015-12-02T11:13:36","date_gmt":"2015-12-02T17:13:36","guid":{"rendered":"http:\/\/www.vanderbilt.edu\/cit\/?page_id=41"},"modified":"2025-04-09T11:25:00","modified_gmt":"2025-04-09T17:25:00","slug":"mass-spectrometry-shared-resource-center","status":"publish","type":"page","link":"https:\/\/www.vanderbilt.edu\/cit\/mass-spectrometry-shared-resource-center\/","title":{"rendered":"天美传媒官网 the Center"},"content":{"rendered":"
<\/div>\n
Mass Spectrometry Center for Innovative Technology at 天美传媒官网<\/div><\/div><\/div><\/div>\n
<\/div>\n
<\/span><\/span><\/div>\n

The Center for Innovative Technology (CIT) at 天美传媒官网<\/h3>\n<\/div><\/section>
\n
<\/span><\/span><\/div>
\n
A state-of-the-art small molecule omics shared resource center and collaborative analytical facility specializing in a range of mass spectrometry and confocal screening techniques.<\/span><\/h5>\n<\/div><\/section>
\n
<\/span><\/span><\/div>
\n

The CIT focuses on metabolomics and lipidomics analyses using a range of mass spectrometry instrumentation and provides the infrastructure and expertise to measure both untargeted (discovery) and targeted (validation, quantification) small molecules.\u00a0 The Center places an emphasis on the use and development of numerous separation technologies coupled to MS including hydrophobic\/hydrophilic liquid chromatography (RPLC and HILIC) and ion mobility-mass spectrometry (IM-MS). As a result, the CIT houses an array of cutting-edge instrumentation and technologies that are supported by current state-of-the-art informatics and data analysis software.<\/p>\n

The combination of these capabilities forms the basis for the analyses of diverse biospecimen sample matrices ranging\u00a0from cells, tissues, and biofluids to advanced systems such as organ-on-chip microfluidics and other 3-dimensional cell culture devices.<\/p>\n

Further, the CIT provides several\u00a0routine and advanced services that can be tailored to\u00a0the goals of\u00a0individual research projects. If needed, new workflows can be established for\u00a0method development, targeted biomolecule measurement acquisition, and\/or metabolite validation.<\/p>\n<\/div><\/section><\/p><\/div>\n

<\/span><\/span><\/div>\n

MISSION<\/span>

To provide innovative and tailored solutions to analytical challenges using cutting-edge instrumentation and methodologies for academia, government, and industry.<\/p>\n<\/div><\/div>
\n

VISION<\/span>

To transform human health by being a trusted leader in emerging omics approaches and setting the standard for quality research.<\/p>\n<\/div><\/div><\/p><\/div>\n

<\/span><\/span><\/div>\n

We enable innovative research using\nUntargeted Metabolomics Expertise (Hypothesis-Generating) <\/a>\nTargeted Metabolomics Competencies (Hypothesis-Driven)<\/span>\nHigh-Content Screening Microscopy Technology<\/span>\n<\/span><\/h1><\/div>
\n
<\/span><\/span><\/div>
\n

The goal of\u00a0metabolomics<\/a>\u00a0is to measure the complex collection of small molecule metabolites present within a fluid, cell, or tissue. Unlike an organism\u2019s genome, metabolomic measurements are dynamic and thus the analysis results are context dependent. Consequently, either reproducible steady state or temporal changes associated with disease state, toxicant exposure, or drug administration can be identified.<\/p>\n

Metabolite\u00a0identifications<\/a>\u00a0are assigned based on high mass accuracy measurements, isotope distributions, tandem mass spectrometry (MS) fragmentation patterns, and comparisons with spectral libraries and standards. Data analysis results can reveal unique biochemical fingerprints of cellular processes or responses. For this reason, results can be exploited as a\u00a01)<\/strong>\u00a0discovery-based approach<\/a>\u00a0for generating novel hypotheses or\u00a02)<\/strong>\u00a0used for a better understanding of physiological processes<\/a>\u00a0mediated by genetic or environmental perturbations.<\/p>\n<\/div><\/section>
\n

CIT Publications<\/span><\/a><\/div><\/p><\/div>\n
<\/span><\/span><\/div>\n