{"id":4729,"date":"2023-06-30T13:09:30","date_gmt":"2023-06-30T18:09:30","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?page_id=4729"},"modified":"2023-07-06T07:41:07","modified_gmt":"2023-07-06T12:41:07","slug":"john-kuriyan","status":"publish","type":"page","link":"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/john-kuriyan\/","title":{"rendered":"John Kuriyan"},"content":{"rendered":"<h2>Signaling proteins mechanism, evolution and structure and ATP-dependent motors in DNA replication<\/h2>\n<figure id=\"attachment_4731\" aria-describedby=\"caption-attachment-4731\" style=\"width: 200px\" class=\"wp-caption alignleft\"><img data-attachment-id=\"4731\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/john-kuriyan\/dean-john-kuriyan\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2023\/06\/29155354\/Kuriyan_Preferred.jpg\" data-orig-size=\"278,300\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;2.8&quot;,&quot;credit&quot;:&quot;天美传媒官网&quot;,&quot;camera&quot;:&quot;ILCE-1&quot;,&quot;caption&quot;:&quot;John Kuriyan, one of the world\\u2019s leading structural biologists, is the next dean of the School of Medicine Basic Sciences.  Kuriyan, Distinguished Professor of Molecular and Cell Biology and professor of chemistry at the University of California, Berkeley, and a Howard Hughes Medical Institute investigator for more than 30 years, will succeed Lawrence J. Marnett, the founding dean of Basic Sciences.&quot;,&quot;created_timestamp&quot;:&quot;1674223563&quot;,&quot;copyright&quot;:&quot;天美传媒官网&quot;,&quot;focal_length&quot;:&quot;51&quot;,&quot;iso&quot;:&quot;250&quot;,&quot;shutter_speed&quot;:&quot;0.0025&quot;,&quot;title&quot;:&quot;Dean John Kuriyan&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Dean John Kuriyan\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;John Kuriyan, Biochemistry Dean, School of Medicine Basic Sciences&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2023\/06\/29155354\/Kuriyan_Preferred.jpg\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2023\/06\/29155354\/Kuriyan_Preferred.jpg\" loading=\"lazy\" class=\"wp-image-4731\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2023\/06\/29155354\/Kuriyan_Preferred.jpg\" alt=\"\" width=\"200\" height=\"216\" \/><figcaption id=\"caption-attachment-4731\" class=\"wp-caption-text\">John Kuriyan, Biochemistry Dean, School of Medicine Basic Sciences<\/figcaption><\/figure>\n<p>The Kuriyan Lab research concerns the workings of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. The laboratory determines the three-dimensional structures of proteins, as well as biochemical, biophysical and cell biological analyses to elucidate how they work. Breakthroughs from the lab have included determining the mechanisms by which several tyrosine kinases, including Src family kinases, the Abl kinase and the epidermal growth factor receptor, switch on and off. These tyrosine kinases are enzymes that are very important targets of drug development in cancer.<\/p>\n<p>Fundamental insights obtained in the Kuriyan Lab have been instrumental in understanding how drugs, such as Gleevec (imatinib) and Scemblix (asciminib), both developed by Novartis, are effective in shutting down the leukemia-causing form of the Abl tyrosine kinase.<\/p>\n<p>The Kuriyan Lab has also provided a fundamental understanding of the structure and regulation of several other signaling proteins, including STATs, the Ras activator SOS, and calcium\/calmodulin-dependent protein kinase-II. The group has also made fundamental contributions to understanding the structural basis for high-speed DNA replication.<\/p>\n<p><a href=\"https:\/\/lab.vanderbilt.edu\/kuriyan-lab\/\" target=\"_blank\" rel=\"noopener\">Kuriyan Lab Homepage<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Signaling proteins mechanism, evolution and structure and ATP-dependent motors in DNA replication The Kuriyan Lab research concerns the workings of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. The laboratory determines the three-dimensional structures of proteins, as well as biochemical, biophysical and cell biological analyses to elucidate how they&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"parent":33,"menu_order":17,"comment_status":"closed","ping_status":"closed","template":"","meta":{"spay_email":""},"tags":[],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/4729"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=4729"}],"version-history":[{"count":11,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/4729\/revisions"}],"predecessor-version":[{"id":4750,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/4729\/revisions\/4750"}],"up":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/33"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=4729"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=4729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}