{"id":820,"date":"2018-07-03T20:46:49","date_gmt":"2018-07-04T01:46:49","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?page_id=820"},"modified":"2023-03-02T09:53:31","modified_gmt":"2023-03-02T15:53:31","slug":"brett-kroncke","status":"publish","type":"page","link":"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/brett-kroncke\/","title":{"rendered":"Brett Kroncke"},"content":{"rendered":"

How do we determine the significance of genetic variance?<\/h2>\n
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Brett Kroncke, Medicine<\/figcaption><\/figure>\n

We want to be able to accurately predict the phenotype of any and all non-synonymous single nucleotide variants in ion channels involved in the heart contraction cycle. Our approach is to collect as much phenotype information – at high and low resolution – as is feasible for the largest number of variants and then leverage experimental and computational structural biology to fill in the details for yet uncharacterized variants.<\/p>\n

Kroncke Lab Homepage<\/a><\/p>\n

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How do we determine the significance of genetic variance? We want to be able to accurately predict the phenotype of any and all non-synonymous single nucleotide variants in ion channels involved in the heart contraction cycle. Our approach is to collect as much phenotype information – at high and low resolution – as is feasible…<\/p>\n","protected":false},"author":1185,"featured_media":0,"parent":33,"menu_order":16,"comment_status":"closed","ping_status":"closed","template":"","meta":{"spay_email":""},"tags":[],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/820"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=820"}],"version-history":[{"count":5,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/820\/revisions"}],"predecessor-version":[{"id":3177,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/820\/revisions\/3177"}],"up":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/pages\/33"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=820"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}