{"id":1478,"date":"2019-02-07T19:15:52","date_gmt":"2019-02-07T19:15:52","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=1478"},"modified":"2019-02-07T19:15:52","modified_gmt":"2019-02-07T19:15:52","slug":"research-spotlight-carlos-lopez-and-tina-iverson","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2019\/02\/07\/research-spotlight-carlos-lopez-and-tina-iverson\/","title":{"rendered":"Research Spotlight: Carlos Lopez and Tina Iverson"},"content":{"rendered":"<p>CSB researchers <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/carlos-lopez\/\" target=\"_blank\" rel=\"noopener\">Carlos Lopez<\/a>, Biochemistry, and <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/tina-iverson\/\" target=\"_blank\" rel=\"noopener\">Tina Iverson<\/a>, Pharmacology, with Vanderbilt faculty Vsevolod Gurevich, have proposed a <a href=\"http:\/\/news.vumc.org\/2019\/01\/17\/signals-conveyer-belt-amplification\/\" target=\"_blank\" rel=\"noopener\">&#8220;conveyor belt&#8221; mechanism<\/a> to explain how scaffold proteins amplify signal cascades by exchanging active enzymes for inactive ones.<\/p>\n<p>Their findings were reported in the <a href=\"https:\/\/www.pnas.org\/content\/116\/3\/810\" target=\"_blank\" rel=\"noopener\"><em>Proceedings of the National Academy of Sciences<\/em><\/a>.<\/p>\n<p><a href=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/02\/19171504\/Lopez_Iverson1.jpg\"><img data-attachment-id=\"1482\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/2019\/02\/07\/research-spotlight-carlos-lopez-and-tina-iverson\/lopez_iverson1\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/02\/19171504\/Lopez_Iverson1.jpg\" data-orig-size=\"400,147\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Lopez_Iverson1\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/02\/19171504\/Lopez_Iverson1-300x110.jpg\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/02\/19171504\/Lopez_Iverson1.jpg\" loading=\"lazy\" class=\"alignleft wp-image-1482 size-medium\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/02\/19171504\/Lopez_Iverson1-300x110.jpg\" alt=\"\" width=\"300\" height=\"110\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/02\/19171504\/Lopez_Iverson1-300x110.jpg 300w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2019\/02\/19171504\/Lopez_Iverson1.jpg 400w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CSB researchers Carlos Lopez, Biochemistry, and Tina Iverson, Pharmacology, with Vanderbilt faculty Vsevolod Gurevich, have proposed a &#8220;conveyor belt&#8221; mechanism to explain how scaffold proteins amplify signal cascades by exchanging active enzymes for inactive ones. Their findings were reported in the Proceedings of the National Academy of Sciences.<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/1478"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=1478"}],"version-history":[{"count":8,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/1478\/revisions"}],"predecessor-version":[{"id":1488,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/1478\/revisions\/1488"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=1478"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=1478"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=1478"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}