{"id":2746,"date":"2020-07-21T15:10:45","date_gmt":"2020-07-21T20:10:45","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=2746"},"modified":"2020-07-21T15:10:45","modified_gmt":"2020-07-21T20:10:45","slug":"research-spotlight-eichman-lab","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2020\/07\/21\/research-spotlight-eichman-lab\/","title":{"rendered":"Research Spotlight: Eichman Lab"},"content":{"rendered":"<p>Eichman lab member Noah Bradley,\u00a0CSB Researcher <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/brandt-eichman\/\" target=\"_blank\" rel=\"noopener\">Brandt Eichman<\/a> and colleagues were recognized by <a href=\"https:\/\/academic.oup.com\/nar\/issue\/48\/13\" target=\"_blank\" rel=\"noopener\"><em>Nucleic Acids Research<\/em><\/a> as the <a href=\"https:\/\/academic.oup.com\/nar\/article\/48\/13\/7005\/5836774\" target=\"_blank\" rel=\"noopener\">NAR Breakthrough Article<\/a> for\u00a0their analysis of a previously uncharacterized DNA repair enzyme from E. coli, YcaQ. The protein belongs to a family of DNA glycosylases, which cleave the bond between a damaged base and the DNA backbone. YcaQ is special in that it specifically recognizes bases that form part of an interstrand crosslink (ICL), one of the most dangerous types of lesions. This type of activity has been observed before, but is not well understood mechanistically. In their study, they demonstrate that YcaQ defines an ICL repair pathway alternative to such systems as the Fanconi anaemia or NER-based pathways.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eichman lab member Noah Bradley,\u00a0CSB Researcher Brandt Eichman and colleagues were recognized by Nucleic Acids Research as the NAR Breakthrough Article for\u00a0their analysis of a previously uncharacterized DNA repair enzyme from E. coli, YcaQ. The protein belongs to a family of DNA glycosylases, which cleave the bond between a damaged base and the DNA backbone&#8230;.<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/2746"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=2746"}],"version-history":[{"count":2,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/2746\/revisions"}],"predecessor-version":[{"id":2748,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/2746\/revisions\/2748"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=2746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=2746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=2746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}