{"id":476,"date":"2017-06-16T21:00:33","date_gmt":"2017-06-16T21:00:33","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=476"},"modified":"2017-06-16T21:00:33","modified_gmt":"2017-06-16T21:00:33","slug":"research-spotlight-walter-chazin","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2017\/06\/16\/research-spotlight-walter-chazin\/","title":{"rendered":"Research Spotlight &#8211; Walter Chazin"},"content":{"rendered":"<p>CSB Researcher <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty\/walter-chazin\/\" target=\"_blank\">Watler Chazin<\/a>, Ph.D., Postdoctoral Fellow Aaron Ehlinger, Ph.D., and colleagues have shown that an ancient primase polymerase &#8211; PrimPol &#8211; helps replicate DNA from cell to cell where there is a damage to DNA.<\/p>\n<p>The study published in <a href=\"http:\/\/www.nature.com\/articles\/ncomms15222\" target=\"_blank\"><em>Nature Communications<\/em><\/a>, demonstrate that PrimPol is recruited to reprime DNA synthesis through its interaction with the essential single-stranded DNA binding Replication Protein A (RPA).\u00a0 The findings provide significant molecular insights into PrimPol&#8217;s role in restarting stalled replication forks.<\/p>\n<p>Read more online in <a href=\"https:\/\/news.vanderbilt.edu\/2017\/06\/12\/repriming-replication-roadblocks\/\" target=\"_blank\"><em>Research News@Vanderbilt<\/em><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CSB Researcher Watler Chazin, Ph.D., Postdoctoral Fellow Aaron Ehlinger, Ph.D., and colleagues have shown that an ancient primase polymerase &#8211; PrimPol &#8211; helps replicate DNA from cell to cell where there is a damage to DNA. The study published in Nature Communications, demonstrate that PrimPol is recruited to reprime DNA synthesis through its interaction with&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/476"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=476"}],"version-history":[{"count":2,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/476\/revisions"}],"predecessor-version":[{"id":478,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/476\/revisions\/478"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}