  {"id":5215,"date":"2024-03-22T11:32:31","date_gmt":"2024-03-22T16:32:31","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=5215"},"modified":"2024-03-22T11:32:31","modified_gmt":"2024-03-22T16:32:31","slug":"illuminating-a-critical-step-in-dna-replication","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2024\/03\/22\/illuminating-a-critical-step-in-dna-replication\/","title":{"rendered":"Illuminating a critical step in DNA replication"},"content":{"rendered":"<figure id=\"attachment_2271\" aria-describedby=\"caption-attachment-2271\" style=\"width: 80px\" class=\"wp-caption alignleft\"><img data-attachment-id=\"2271\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/brandt-eichman\/eichman2019-web-2\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2.jpg\" data-orig-size=\"858,1077\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"eichman2019-web-2\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Brandt Eichman, Biological Sciences&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2-239x300.jpg\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2-816x1024.jpg\" loading=\"lazy\" class=\"wp-image-2271\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2-816x1024.jpg\" alt=\"\" width=\"80\" height=\"100\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2-816x1024.jpg 816w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2-239x300.jpg 239w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2-768x964.jpg 768w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2020\/02\/19171453\/eichman2019-web-2.jpg 858w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><figcaption id=\"caption-attachment-2271\" class=\"wp-caption-text\">Brandt Eichman, Biological Sciences<\/figcaption><\/figure>\n<figure id=\"attachment_3888\" aria-describedby=\"caption-attachment-3888\" style=\"width: 84px\" class=\"wp-caption alignleft\"><img data-attachment-id=\"3888\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/walter-chazin\/wjc2-2\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2022\/06\/19203854\/WJC2.jpg\" data-orig-size=\"200,237\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"WJC2\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Walter Chazin, Biochemistry and Chemistry&lt;\/p&gt;\n\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2022\/06\/19203854\/WJC2.jpg\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2022\/06\/19203854\/WJC2.jpg\" loading=\"lazy\" class=\"wp-image-3888\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2022\/06\/19203854\/WJC2.jpg\" alt=\"\" width=\"84\" height=\"100\" \/><figcaption id=\"caption-attachment-3888\" class=\"wp-caption-text\">Walter Chazin, Biochemistry and Chemistry<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/brandt-eichman\/\">Brandt Eichman<\/a> (Biological Sciences) and <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/walter-chazin\/\">Walter Chazin<\/a> (Biochemistry and Chemistry) recently visualized a multi-functional protein in action using the state-of-the-art <a href=\"https:\/\/www.vanderbilt.edu\/csb\/facilities\/cryo-electron-microscopy\/\">CSB Cryo-EM Facility<\/a>. <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01227-4\" target=\"_blank\" rel=\"noopener\">The findings<\/a>, recently published in <a href=\"https:\/\/www.nature.com\/nsmb\/\" target=\"_blank\" rel=\"noopener\"><em>Nature Structural &amp; Molecular Biology<\/em><\/a>, shed light on how DNA replication is initiated in humans.<\/p>\n<p><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2024\/03\/15\/qa-illuminating-a-critical-step-in-initiating-dna-replication-in-eukaryotes\/\" target=\"_blank\" rel=\"noopener\">Read their reflections<\/a> on this critical research in this Q&amp;A with the Basic Sciences Communications Team.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brandt Eichman (Biological Sciences) and Walter Chazin (Biochemistry and Chemistry) recently visualized a multi-functional protein in action using the state-of-the-art CSB Cryo-EM Facility. The findings, recently published in Nature Structural &amp; Molecular Biology, shed light on how DNA replication is initiated in humans. Read their reflections on this critical research in this Q&amp;A with the&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5215"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=5215"}],"version-history":[{"count":10,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5215\/revisions"}],"predecessor-version":[{"id":5226,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5215\/revisions\/5226"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=5215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=5215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=5215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}