{"id":6393,"date":"2026-02-05T08:09:52","date_gmt":"2026-02-05T14:09:52","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=6393"},"modified":"2026-02-19T12:19:47","modified_gmt":"2026-02-19T18:19:47","slug":"csb-research-spotlight-sanders-lab-promising-small-molecule-may-help-with-sudden-cardiac-death","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2026\/02\/05\/csb-research-spotlight-sanders-lab-promising-small-molecule-may-help-with-sudden-cardiac-death\/","title":{"rendered":"CSB Research Spotlight: Sanders Lab\u2014Promising small molecule may help with sudden cardiac death"},"content":{"rendered":"

\"\"Long QT syndrome (LQTS) is a hereditary or acquired cardiac disorder that affects the electrical system of the heart, which causes a delay in the heart\u2019s repolarization or reset time. This delay means the heart takes longer to reset between beats.<\/p>\n

LQTS is a fatal disorder linked to syncope, arrhythmia, and cardiac arrest. Type 1 Long QT syndrome (LQT1) accounts for close to half of congenital LQTS and is caused by loss-of-function mutations in the voltage-gated potassium channel KCNQ1.<\/p>\n

The Sanders lab recently investigated whether a small molecule could help these channel proteins work better, with a goal that one day it might help treat long QT syndrome.<\/p>\n

Read more about this study on the SBGrid Community News<\/em><\/a>.<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Long QT syndrome (LQTS) is a hereditary or acquired cardiac disorder that affects the electrical system of the heart, which causes a delay in the heart\u2019s repolarization or reset time. This delay means the heart takes longer to reset between beats. LQTS is a fatal disorder linked to syncope, arrhythmia, and cardiac arrest. Type 1…<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6393"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=6393"}],"version-history":[{"count":3,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6393\/revisions"}],"predecessor-version":[{"id":6411,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6393\/revisions\/6411"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=6393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=6393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=6393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}