  {"id":6412,"date":"2026-02-20T09:00:41","date_gmt":"2026-02-20T15:00:41","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=6412"},"modified":"2026-02-20T09:00:41","modified_gmt":"2026-02-20T15:00:41","slug":"csb-research-spotlight-lacy-lab-novel-vaccine-protects-against-c-diff-disease-and-recurrence","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2026\/02\/20\/csb-research-spotlight-lacy-lab-novel-vaccine-protects-against-c-diff-disease-and-recurrence\/","title":{"rendered":"CSB Research Spotlight: Lacy Lab\u2014Novel vaccine protects against C. diff disease and recurrence"},"content":{"rendered":"<p><img data-attachment-id=\"5360\" data-permalink=\"https:\/\/www.vanderbilt.edu\/csb\/2024\/06\/14\/research-spotlight-fesik-lab\/csb-research-spotlight\/\" data-orig-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" data-orig-size=\"500,300\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"CSB Research Spotlight\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png\" data-large-file=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png\" loading=\"lazy\" class=\"alignleft wp-image-5360 size-medium\" src=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png\" alt=\"\" width=\"300\" height=\"180\" srcset=\"https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight-300x180.png 300w, https:\/\/cdn.vanderbilt.edu\/vu-URL\/wp-content\/uploads\/sites\/212\/2024\/06\/14085600\/CSB-Research-Spotlight.png 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>Clostridioides difficile (C. diff) is the leading cause of health care\u2013 and antibiotic\u2013associated infection. It causes diarrhea and colitis (inflammation of the colon) and nearly half a million C. diff infections in the U.S. each year and about 29,000 deaths, resulting in an estimated $4.8 billion in health care costs. People taking antibiotics; those who have had a recent hospitalization or live in a health care facility; and adults over 65 are most at risk of C. diff infection. There are limited treatments and no vaccines, and up to 30% of patients have a recurrent C. diff infection after initial treatment.<\/p>\n<p>A group of Vanderbilt researchers, led by the <a href=\"https:\/\/www.vanderbilt.edu\/csb\/faculty-core\/borden-lacy\/\" target=\"_blank\" rel=\"noopener\">Lacy lab<\/a>, developed a novel vaccination approach that cleared the harmful gut bacterium C. diff in an animal model of infection.<\/p>\n<p><a href=\"https:\/\/news.vumc.org\/2026\/02\/18\/novel-vaccine-protects-against-c-diff-disease-and-recurrence\/\" target=\"_blank\" rel=\"noopener\">Read more<\/a> about this major step forward for C. diff vaccine development at Vanderbilt Health News.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clostridioides difficile (C. diff) is the leading cause of health care\u2013 and antibiotic\u2013associated infection. It causes diarrhea and colitis (inflammation of the colon) and nearly half a million C. diff infections in the U.S. each year and about 29,000 deaths, resulting in an estimated $4.8 billion in health care costs. People taking antibiotics; those who&#8230;<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6412"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=6412"}],"version-history":[{"count":2,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6412\/revisions"}],"predecessor-version":[{"id":6414,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/6412\/revisions\/6414"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=6412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=6412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=6412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}