Technological Advancements
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Abstract
National Library of Medicine National Center for Biotechnology Information
A novel mouse home cage lickometer system reveals sex- and housing-based influences on alcohol drinking
Alcohol use disorder (AUD) is a significant global health issue. Despite historically higher rates among men, AUD prevalence and negative alcohol-related outcomes in women are rising. Loneliness in humans has been associated with increased alcohol use, and traditional rodent drinking models involve single housing, presenting challenges for studying social enrichment.
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Abstract
National Library of Medicine National Center for Biotechnology Information
Structured tracking of alcohol reinforcement (STAR) for basic and translational alcohol research
There is inherent tension between methodologies developed to address basic research questions in model species and those intended for preclinical to clinical translation: basic investigations require flexibility of experimental design as hypotheses are rapidly tested and revised, whereas preclinical models emphasize standardized protocols and specific outcome measures.
Papers
Research Findings
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Abstract
National Library of Medicine National Center for Biotechnology Information
Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder
Maintaining abstinence from alcohol use disorder (AUD) is extremely challenging, partially due to increased symptoms of anxiety and stress that trigger relapse. Rodent models of AUD have identified that the bed nucleus of the stria terminalis (BNST) contributes to symptoms of anxiety-like behavior and drug-seeking during abstinence. In humans, however, the BNST鈥檚 role in abstinence remains poorly understood.聽
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